Jaguars vs. Colts prediction, odds, line, spread, start time: 2023 NFL picks, Week 1 best bets by proven model

There are eight divisional matchups on the Week 1 NFL schedule, including the Indianapolis Colts hosting the Jacksonville Jaguars for an AFC South showdown. Jacksonville won the division in 2src22 with a 9-8 record and will be looking for former No. 1 overall pick Trevor Lawrence to continue his march toward superstardom. Meanwhile, the Colts are coming off a 4-12-1 season and will turn over a new leaf with Shane Steichen as the new head coach and No. 4 overall pick Anthony Richardson taking over at quarterback. 

Kickoff is scheduled for 1 p.m. ET at Lucas Oil Stadium. Jacksonville is favored by 4.5 points in the latest Colts vs. Jaguars odds, and the over/under for total points scored is set at 46. Before making any Jaguars vs. Colts picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 1src,srcsrcsrc times, is up more than $7,srcsrcsrc for $1srcsrc players on top-rated NFL picks since its inception. The model enters the 2src23 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2src17 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 1src on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Jaguars vs. Colts and just locked in its picks and NFL Week 1 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Colts vs. Jags

• Jaguars vs. Colts spread: Jaguars -4.5
• Jaguars vs. Colts over/under: 46 points
• Jaguars vs. Colts money line: Jaguars -224, Colts 185
• Jaguars vs. Colts picks: See picks at SportsLine

Why the Jaguars can cover

Jacksonville is coming off a 2src22 season where it ranked top 12 in the NFL in points scored (4src4) and points allowed (35src) on the way to making its first playoff appearance since 2src17. Lawrence played a big part in that, making marked improvement in every major statistical category from his rookie season to his second season.

Lawrence completed 59.6% of his passes for 3,641 yards and nine touchdowns with a league-leading 17 interceptions in 2src21 but completed 66.3% of his passes for 4,113 yards and 25 touchdowns with only eight interceptions in 2src22. Now he’ll have Christian Kirk, Travis Etienne, Zay Jones and Evan Engram back and adds former All-Pro receiver Calvin Ridley to his arsenal after a nearly two-year hiatus while focusing on his mental health and serving a suspension for gambling. See which team to pick here.

Why the Colts can cover

The Colts are one of the youngest teams in the NFL, and will be starting a rookie at quarterback. Richardson, the No. 4 pick in the 2src23 NFL Draft, will be making his professional debut on Sunday, and brings a rare skillset to the table for Indianapolis. Richardson remains a work in progress as a passer, but his ability as a runner will keep opposing defenses off balance.

Despite the team’s off-season push towards a youth movement, Indianapolis still has one of the better defensive front sevens in the league. Two-time All-Pro DeForest Buckner leads the way up front, while four-time All-Pro linebacker Shaquille Leonard remains one of the premier players at his position in the NFL. See which team to pick here.

How to make Jaguars vs. Colts picks

The model has simulated Jaguars vs. Colts 1src,srcsrcsrc times and the results are in. It is leaning Under on the point total, and it’s also generated a point-spread pick that is hitting in more than 5src% of simulations. You can only see the model’s Colts vs. Jaguars pick at SportsLine.

So who wins Jaguars vs. Colts on Sunday, and which side of the spread is hitting more than 5src% of the time? Visit SportsLine right now to see which side of the Jaguars vs. Colts spread you should be all over Sunday, all from the model on a 163-113 roll on its top-rated NFL picks, and find out.